Blar i forfatter "Widnes, Christian"

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    • Longitudinal reference ranges for maternal plasma laeverin, and its role as a potential biomarker of preeclampsia 

      Nystad, Mona; Sitras, Vasilis; Flo, Kari; Widnes, Christian; Vårtun, Åse; Wilsgaard, Tom; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-25)
      Background: Laeverin is a placenta-specific membrane-bound aminopeptidase. In this study we wanted to: 1) serially measure plasma levels of laeverin in healthy women during the second half of pregnancy and postpartum, 2) determine whether laeverin is differently expressed at 22–24 weeks in women who later develop preeclampsia compared to controls, 3) compare laeverin protein expression in placenta ...

    • Maternal cardiac function, uterine artery hemodynamics and natriuretic peptides at 22-24 weeks of gestation and subsequent development of hypertensive disorders of pregnancy 

      Liang, Huan; Vårtun, Åse; Flo, Kari; Widnes, Christian; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-26)
      <p><i>Introduction - </i>Maternal cardiac dysfunction as well as abnormal uterine artery (UtA) Doppler are associated with hypertensive disorders of pregnancy (HDP), but their relation is unclear. We investigated the correlation between maternal cardiac function, UtA hemodynamics and natriuretic peptides, and explored differences between women who subsequently developed HDP and those who did ...

    • Sex differences in placental circulation 

      Widnes, Christian (Doctoral thesis; Doktorgradsavhandling, 2020-04-03)
      Sexual dimorphism in placental morphology and function has increasingly been acknowledged. The differences in adaptation to the intrauterine environment and in perinatal/neonatal outcomes between the sexes has been well described. Doppler-derived hemodynamic parameters of the feto-placental and utero-placental circulations are commonly used to monitor fetal wellbeing in clinical practice, but whether ...

    • Sex differences in umbilical artery Doppler indices: A longitudinal study 

      Widnes, Christian; Flo, Kari; Wilsgaard, Tom; Kiserud, Torvid; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-18)
      <p><i>Background</i>: Sexual dimorphism in placental size and function has been described. Whether this influences the clinically important umbilical artery (UA) waveform remains controversial, although a few cross-sectional studies have shown sex differences in UA pulsatility index (PI). Therefore, we tested whether fetal sex influences the UA Doppler indices during the entire second half of pregnancy ...

    • Static and functional hemodynamic profiles of women with abnormal uterine artery doppler at 22-24 weeks of gestation 

      Vårtun, Åse; Flo, Kari; Widnes, Christian; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      Objective To compare cardiac function, systemic hemodynamics and preload reserve of women with increased (cases) and normal (controls) uterine artery (UtA) pulsatility index (PI) at 22–24 weeks of gestation. Materials and Methods A prospective cross-sectional study of 620 pregnant women. UtA blood flow velocities were measured using Doppler ultrasonography, and PI was calculated. Mean UtA ...